Androgenic alopecia (AGA) ndi mtundu wamba wa tsitsi lomwe limatayika chifukwa cha cholowa ndi mahomoni, omwe amadziwika ndi kuwonda tsitsi lamutu.Pakati pa zaka 60, 45% ya amuna ndi 35% ya amayi akukumana ndi vuto la AGA.FDA idavomereza ma protocol a AGA akuphatikiza oral finasteride ndi topical minoxidil.Pakalipano, chifukwa cha kusowa kwa chithandizo chamankhwala, PRP yakhala njira yatsopano yopangira chithandizo.Zinthu zambiri za kukula mu PRP zimatha kulimbikitsa kusinthika kwa tsitsi ndi mapulateleti α Mitundu yosiyanasiyana ya kukula yomwe imatulutsidwa ndi granules imachita pa maselo a tsinde mumtundu wa tsitsi lotupa ndikulimbikitsa mapangidwe atsopano a mitsempha ya magazi.Ngakhale kuti nkhani zambiri zanena izi, palibe ndondomeko yokhazikika yokonzekera PRP, njira yoyendetsera kayendetsedwe ka kayendetsedwe ka kayendetsedwe ka kayendetsedwe ka kayendetsedwe ka kayendetsedwe ka kayendetsedwe ka kayendetsedwe ka kayendetsedwe ka kayendetsedwe kake.Nkhaniyi ikufuna kuwunika momwe PRP imagwirira ntchito pochiza AGA ndikuwunika mankhwala omwe alipo.
Zochita za PRP:
PRP imatsegulidwa pambuyo pobayidwa mu scalp kuti amasule zinthu zambiri za kukula ndikulimbikitsa kukula kwa tsitsi.Zinthu zakukula izi zimatha kuyambitsa ma fibroblasts, kulimbikitsa kaphatikizidwe ka collagen, kupititsa patsogolo katulutsidwe ka matrix a extracellular ndikuwongolera mafotokozedwe azinthu zakukulira.Zinthu za kukula (PDGF, TGF- β, VEGF, EGF, IGF-1) zimatha kulimbikitsa kukula kwa maselo ndi kusiyanitsa, maselo a chemotactic stem, kuchititsa kukula kwa tsitsi lalitali, ndi kulimbikitsa follicle angiogenesis ya tsitsi.Zinthu zina (serotonin, histamine, dopamine, calcium ndi adenosine) zimatha kuwonjezera kufalikira kwa membrane ndikuwongolera kutupa.
Kukonzekera kwa PRP:
Njira zonse zokonzekera za PRP zimatsatira lamulo lodziwika bwino, ndipo anticoagulants (monga citrate) amawonjezeredwa ku magazi osonkhanitsidwa kuti apewe kuphatikizika kwachisawawa ndi kuyambitsa mapulateleti.Centrifuge kuchotsa maselo ofiira amwazi ndikuyika mapulateleti.Kuphatikiza apo, ma ziwembu ambiri amasankha ma exogenous platelet activators (monga thrombin ndi calcium chloride) kuti alimbikitse kutulutsidwa kwa zinthu zakukulira kuchokera ku mapulateleti motengera mlingo.Mapulateleti osagwiritsidwa ntchito amathanso kuyambitsidwa ndi dermal collagen kapena autothrombin.Nthawi zambiri, kukula kogwira ntchito kumatulutsidwa mphindi 10 mutatha kuyambitsa, ndipo 95% yazinthu zomwe zimapangidwira zimatulutsidwa mkati mwa ola limodzi, zomwe zimakhala kwa sabata limodzi.
Dongosolo la chithandizo ndi kukhazikika kwake:
PRP nthawi zambiri imabayidwa pansi pa khungu kapena intradermally.Pakali pano, mulingo woyenera kwambiri mankhwala pafupipafupi ndi imeneyi sizinakhazikitsidwe.Kuchuluka kwa PRP ndi chinthu chofunikira chomwe chimakhudza zotsatira zachipatala.Zolemba zisanu ndi ziwiri zomwe zikuphatikizidwa zimayika patsogolo kuti kuchuluka kwabwino kwa PRP ndi nthawi za 2 ~ 6, ndipo ndende yochulukirapo idzalepheretsa angiogenesis.Padakali mkangano ngati ili ndi maselo oyera a magazi.
Zotsatira za kafukufuku wamakono zikuwonetsa zimenezoPRP ingagwiritsidwe ntchito pochiza AGA.Maphunziro asanu ndi awiri mwa asanu ndi anayi adafotokoza zotsatira zabwino.Mphamvu ya PRP idawunikidwa kuchokera kuzinthu zingapo: njira yodziwira PTG, kuyesa kupsinjika kwa tsitsi, kuchuluka kwa tsitsi ndi kachulukidwe ka tsitsi, nthawi yakukula mpaka nthawi yopumula, ndi kafukufuku wokhutitsidwa ndi odwala.Kafukufuku wina adangowonetsa zotsatira zabwino zakutsatira kwa miyezi ya 3 pambuyo pa chithandizo cha PRP, koma analibe zotsatira zotsatila za miyezi ya 6.Maphunziro ena otsatiridwa kwa nthawi yayitali (miyezi 6 mpaka 12) adanenanso kuchepa kwa kachulukidwe ka tsitsi, koma anali akadali apamwamba kuposa mulingo woyambira.Zotsatira zoyipa zidanenedwa ngati kupweteka kwakanthawi m'dera la jekeseni.Palibe zoyipa zomwe zidanenedwa.
Chithandizo choyenera:
Popeza PRP sichiletsa mlingo wa mahomoni okhudzana ndi AGA, ndi bwino kuti PRP igwiritsidwe ntchito ngati chithandizo cha adjuvant kwa AGA.Choncho, odwala ayenera kulimbikitsidwa kusunga mankhwala apakhungu kapena pakamwa (monga minoxidil, spironolactone ndi finasteride).Kutengera ndi kafukufuku wobwerera m'mbuyo, tikulimbikitsidwa kukonzekera P-PRP (leukopenia) ndi ndende nthawi 3-6 kuposa magazi athunthu.Kugwiritsa ntchito ma activator (calcium chloride kapena calcium gluconate) musanalandire chithandizo kumathandizira kumasula zinthu zakukula.Akuti jekeseni wa subcutaneous ayenera kuchitidwa kuchokera ku gawolo ndi tsitsi lochepa, pambali pa tsitsi ndi pamwamba, ndipo malo ojambulira ayenera kupatulidwa.Mlingo wa jakisoni umatsimikiziridwa ndi zosowa zachipatala.Kuchuluka kwa jakisoni kumasankhidwa panjira yoyamba yamankhwala (kamodzi pamwezi, katatu konse, miyezi itatu), ndiyeno kamodzi miyezi itatu iliyonse, katatu konse (ndiko kuti, kamodzi mu Juni, Seputembala ndi Disembala motsatana).Inde, pambuyo pa njira yoyamba ya mankhwala, ndi othandizanso kusintha nthawi yapakati kamodzi pa miyezi isanu ndi umodzi.Kawirikawiri, odwala aamuna ndi aakazi apeza zotsatira zabwino pakukulanso tsitsi, kuwonjezeka kwa tsitsi komanso kusintha kwa moyo pambuyo pobaya PRP kuti athetse AGA (Chithunzi 1 ndi Chithunzi 2).
Pomaliza:
Kuwunika kwa zotsatira zingapo za kafukufuku kukuwonetsa kuti PRP ikulonjeza pochiza AGA.Panthawi imodzimodziyo, chithandizo cha PRP chikuwoneka ngati chotetezeka komanso chochepa.Komabe, palibe kusowa kwa njira yokonzekera PRP yokhazikika, ndondomeko, ndondomeko ya jekeseni, mlingo, ndi zina zotero. Choncho, n'zovuta kuyesa momwe PRP imathandizira.Kuti mupitirize kuphunzira zotsatira za PRP pa kusinthika kwa tsitsi mu AGA, kukula kwachitsanzo chokulirapo cha mayesero olamulidwa mwachisawawa (onani mafupipafupi a jekeseni, kusakanikirana kwa PRP, ndi kukwaniritsa kutsata kwa nthawi yaitali) kumafunika.
(Zomwe zili m'nkhaniyi zidasindikizidwanso, ndipo sitikupereka chitsimikizo chotsimikizika kapena chotsimikizika pakulondola, kudalirika kapena kukwanira kwa zomwe zili m'nkhaniyi, ndipo sitili ndi udindo pamalingaliro ankhaniyi, chonde mvetsetsani.）
Nthawi yotumiza: Dec-08-2022