Androgenic alopecia (AGA), mtundu wofala kwambiri wa kutha kwa tsitsi, ndi vuto lomwe limayamba muunyamata kapena unyamata mochedwa.Kuchuluka kwa amuna m'dziko langa ndi pafupifupi 21.3%, ndipo kuchuluka kwa akazi ndi pafupifupi 6.0%.Ngakhale akatswiri ena apereka malangizo okhudza matenda ndi chithandizo cha androgenetic alopecia ku China m'mbuyomu, amangoganizira za matenda ndi chithandizo chamankhwala cha AGA, ndipo njira zina zothandizira zikusowa.M'zaka zaposachedwa, ndikugogomezera chithandizo cha AGA, njira zina zatsopano zothandizira zatuluka.
Etiology ndi Pathogenesis
AGA ndi matenda a genetic predisposed polygenic recessive.Kafukufuku wokhudzana ndi matenda a m'banja amasonyeza kuti 53.3% -63.9% ya odwala AGA ali ndi mbiri ya banja, ndipo mzere wa abambo ndi wapamwamba kwambiri kuposa mzere wa amayi.Kafukufuku waposachedwa wa ma genome athunthu komanso mapu apeza mitundu ingapo yowopsa, koma majini awo oyambitsa matenda sanadziwikebe.Kafukufuku waposachedwa akuwonetsa kuti ma androgens amatenga gawo lofunikira pakuyambitsa matenda a AGA;zinthu zina kuphatikizapo kutupa kuzungulira tsitsi, kuwonjezereka kwa moyo, kupsyinjika ndi nkhawa, komanso kusakhala ndi makhalidwe abwino ndi kudya kungawonjezere zizindikiro za AGA.Androgens mwa amuna makamaka amachokera ku testosterone yotulutsidwa ndi ma testes;androgens mwa akazi makamaka amachokera ku kaphatikizidwe ka adrenal cortex ndi katulutsidwe kakang'ono kuchokera ku thumba losunga mazira, androgen makamaka ndi androstenediol, yomwe imatha kusinthidwa kukhala testosterone ndi dihydrotestosterone.Ngakhale kuti ma androgens ndi chinthu chofunikira kwambiri pa matenda a AGA, ma androgens ozungulira pafupifupi odwala onse a AGA amasungidwa bwino.Kafukufuku wasonyeza kuti zotsatira za androgens pazitsulo zowonongeka zimawonjezeka chifukwa cha kuwonjezeka kwa androgen receptor gene expression ndi / kapena kuwonjezeka kwa mtundu wa II 5α reductase jini muzitsulo za tsitsi m'dera la alopecia.Kwa AGA, ma cell a dermal chigawo cha ma follicles atsitsi amakhala ndi mtundu wina wa II 5α reductase, womwe ungasinthe testosterone ya androgen yomwe imazungulira m'dera la magazi kukhala dihydrotestosterone pomangirira ku intracellular androgen receptor.Kuyambitsa zinthu zingapo zomwe zimatsogolera kukukula pang'onopang'ono kwa ma follicle atsitsi ndikuthothoka tsitsi mpaka kumeta.
Zowonetsera Zachipatala ndi Malangizo a Chithandizo
AGA ndi mtundu wa alopecia wosabala womwe umayamba nthawi yaunyamata ndipo umadziwika ndi kuwonda pang'onopang'ono kwa m'mimba mwake, kuthothoka kwa tsitsi, ndi alopecia mpaka kumeta kosiyanasiyana, komwe nthawi zambiri kumatsagana ndi zizindikiro za kuchuluka kwa mafuta a m'mutu.
Pulogalamu ya PRP
Mlingo wa kupatsidwa zinthu za m`mwazi ndi wofanana ndi ndende ya 4-6 nthawi ya kupatsidwa zinthu za m`mwazi m'magazi athunthu.PRP ikangotsegulidwa, ma granules a α m'mapulateleti adzatulutsa zinthu zambiri za kukula, kuphatikizapo platelet-derived growth factor, kusintha kukula-β, insulini-monga kukula factor, epidermal kukula factor ndi vascular endothelial growth factor, etc. zolimbikitsa kukula kwa follicle ya tsitsi, koma njira yeniyeni yochitirapo kanthu sizidziwika bwino.Kugwiritsiridwa ntchito ndiko kubaya PRP kumaloko mu dermis wosanjikiza wa scalp m'dera alopecia, kamodzi pamwezi, ndi jekeseni mosalekeza 3 kwa 6 nthawi akhoza kuona zotsatira zina.Ngakhale kuti maphunziro osiyanasiyana azachipatala kunyumba ndi kunja adatsimikiziratu kuti PRP ili ndi zotsatira zina pa AGA, palibe ndondomeko yofanana yokonzekera PRP, kotero kuti mlingo wothandiza wa chithandizo cha PRP si yunifolomu, ndipo ukhoza kugwiritsidwa ntchito ngati wothandizira. kutanthauza chithandizo cha AGA pakadali pano.
(Zomwe zili m'nkhaniyi zidasindikizidwanso, ndipo sitikupereka chitsimikizo chotsimikizika kapena chotsimikizika pakulondola, kudalirika kapena kukwanira kwa zomwe zili m'nkhaniyi, ndipo sitili ndi udindo pamalingaliro ankhaniyi, chonde mvetsetsani.）
Nthawi yotumiza: Aug-02-2022