PRP imagwira ntchito pochotsa ma alpha granules kuchokera ku mapulateleti, omwe ali ndi zinthu zingapo zakukulira.Katulutsidwe wogwira wa zinthu izi kukula umayamba ndi magazi coagulation ndi kuyamba mkati mphindi 10 coagulation.Zoposa 95% za zinthu zomwe zidapangidwa kale zimatulutsidwa mkati mwa ola limodzi.Choncho, PRP iyenera kukonzedwa mumtundu wa anticoagulant ndipo iyenera kugwiritsidwa ntchito pazitsulo, zophimba, kapena mabala mkati mwa maminiti a 10 kuchokera pamene magazi ayamba.Maphunziro omwe sagwiritsa ntchito magazi athunthu a anticoagulated sizowona maphunziro a PRP ndipo akusocheretsa.
Pamene mapulateleti amayendetsedwa ndi kutsekeka, zinthu zakukulira zimatulutsidwa kuchokera ku selo kudzera mu nembanemba ya cell.Pochita izi, tinthu tating'onoting'ono ta alpha timaphatikizana ndi nembanemba zama cell cell, ndipo kukula kwa mapuloteni kumamaliza bioactive state powonjezera unyolo wam'mbali wa histone ndi carbohydrate ku mapuloteniwa.Chifukwa chake, mapulateleti owonongeka kapena osagwiritsidwa ntchito ndi chithandizo cha PRP samatulutsa zinthu zakukulira kwa bioactive ndipo zingayambitse zotsatira zokhumudwitsa.Zinthu zobisika zakukula zimamanga nthawi yomweyo kumtunda wakunja kwa nembanemba ya ma cell omwe ali mumtengo, mphira, kapena bala kudzera pa ma transmembrane receptors.
Kafukufuku wasonyeza kuti munthu wamkulu mesenchymal tsinde maselo, osteoblasts, fibroblasts, endothelial maselo, ndi maselo a epidermal amaonetsa cell membrane zolandilira zinthu kukula mu PRP.Ma transmembrane receptors nawonso amapangitsa kuyambitsa kwa mapuloteni olowa mkati omwe amatsogolera ku kufotokozera (kutsegula) kwamayendedwe amtundu wa cell, monga kuchuluka kwa ma cell, mapangidwe a matrix, mapangidwe a osteoid, kaphatikizidwe ka collagen, ndi zina zambiri.
Kufunika kwa chidziwitso ichi ndikuti zinthu za kukula kwa PRP sizilowa mu selo kapena phata lake, sizili mutagenic, zimangowonjezera kulimbikitsa machiritso abwino.Chifukwa chake, PRP ilibe kuthekera koyambitsa chotupa.
Pambuyo pa kuphulika koyamba kwa zinthu zomwe zimayenderana ndi kukula kwa PRP, mapulateleti amapangidwa ndikutulutsa zinthu zina zakukula kwa masiku 7 otsala a moyo wawo.Mapulateleti akatha ndi kufa, ma macrophages omwe amafika m'derali kudzera m'mitsempha yamagazi yolimbikitsidwa ndi mapulateleti amakulira mkati kuti atenge gawo lowongolera machiritso a zilonda pobisa zinthu zina zomwe zimakula komanso zina.Motero, kuchuluka kwa mapulateleti amene ali mu phata, pabala, kapena magazi amene amaundana pa nthitiyo amatsimikizira mmene balalo limachira msanga.PRP imangowonjezera nambala imeneyo.
Ndi mapulateleti angati okwanira?
Kafukufuku wasonyeza kuti kuchulukana ndi kusiyanitsa kwa akuluakulu a MSCS kumagwirizana mwachindunji ndi ndende ya mapulateleti.Iwo adawonetsa ma curve-mayankho a mlingo, omwe adawonetsa kuti kuyankhidwa kokwanira kwa ma cell kuma cell a platelet kunayamba pomwe kanayi kapena kasanu kuchuluka kwa mapulateleti oyambira kudafikira.Kafukufuku wofananawo adawonetsa kuti kuchuluka kwa mapulateleti kumathandiziranso kuchulukana kwa fibroblast ndi mtundu wa I collagen kupanga, komanso kuti mayankho ambiri anali odalira PH, ndipo kuyankha kwabwino kumachitika pamilingo ya acidic pH.
Maphunzirowa samangosonyeza kufunikira kwa zipangizo kuti zikhazikitse mapulateleti okwanira, komanso kufotokozera zotsatira zowonjezereka za kusinthika kwa mafupa ndi zotsatira za minofu yofewa yokhudzana ndi PRP.
Popeza anthu ambiri ali ndi chiwerengero cha maselo a magazi cha 200,000±75,000 pa μl, chiwerengero cha PRP cha platelet cha 1 miliyoni pa μl choyezedwa mu 6-ml aliquots chokhazikika chakhala chizindikiro cha "chithandizo cha PRP."Chofunika kwambiri, kafukufuku wasonyeza kuti kuphatikizika kwa mapulateleti uku kumatheka pamene milingo yamankhwala ifika, motero kumasula zinthu zakukulira.
(Zomwe zili m'nkhaniyi zidasindikizidwanso, ndipo sitikupereka chitsimikizo chotsimikizika kapena chotsimikizika pakulondola, kudalirika kapena kukwanira kwa zomwe zili m'nkhaniyi, ndipo sitili ndi udindo pamalingaliro ankhaniyi, chonde mvetsetsani.）
Nthawi yotumiza: Sep-01-2022