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Kumvetsetsa Kwatsopano kwa Platelet Rich Plasma Therapy (PRP) - Gawo I

Ma cell a autologous cell therapy pogwiritsa ntchito plasma-rich plasma (PRP) atha kukhala ndi gawo lothandizira pamapulani osiyanasiyana amankhwala obwezeretsanso.Pali kufunikira kosakwanira kwapadziko lonse kwa njira zokonzetsera minyewa pochiza odwala omwe ali ndi minofu ndi mafupa (MSK) ndi matenda a msana, osteoarthritis (OA) ndi mabala osatha komanso osasinthika.Thandizo la PRP limachokera ku mfundo yakuti platelet growth factor (PGF) imathandizira machiritso a mabala ndi kukonza zowonongeka (kutupa, kufalikira ndi kukonzanso).Mapangidwe angapo a PRP adawunikidwa kuchokera ku maphunziro a anthu, mu vitro ndi nyama.Komabe, malingaliro a in vitro ndi maphunziro a zinyama nthawi zambiri amabweretsa zotsatira zosiyana zachipatala, chifukwa n'zovuta kumasulira zotsatira zosagwirizana ndi zachipatala ndi ndondomeko za njira zothandizira anthu.M'zaka zaposachedwa, kupita patsogolo kwapangidwa pakumvetsetsa lingaliro laukadaulo wa PRP ndi ma biological agents, ndipo malangizo atsopano ofufuza ndi ziwonetsero zatsopano zaperekedwa.Mu ndemangayi, tidzakambirana zaposachedwa kwambiri pokonzekera ndi kupanga PRP, kuphatikizapo mlingo wa platelet, ntchito ya leukocyte ndi innate and adaptive immune regulation, 5-hydroxytryptamine (5-HT) zotsatira ndi kupweteka.Kuonjezera apo, tinakambirana njira ya PRP yokhudzana ndi kutupa ndi angiogenesis panthawi yokonza minofu ndi kusinthika.Pomaliza, tiwonanso zotsatira za mankhwala ena pazochitika za PRP.

 

Autologous platelet-rich plasma (PRP) ndi gawo lamadzimadzi lamagazi otumphukira a autologous pambuyo pa chithandizo, ndipo kuchuluka kwa mapulateleti kumakhala kwakukulu kuposa koyambira.Thandizo la PRP lakhala likugwiritsidwa ntchito kwa zizindikiro zosiyanasiyana kwa zaka zoposa 30, zomwe zimapangitsa chidwi chachikulu pa kuthekera kwa PRP yodziwikiratu mu mankhwala obwezeretsa.Mawu akuti orthopaedic biological agent adayambitsidwa posachedwapa kuti azichiza matenda a musculoskeletal (MSK), ndipo apeza zotsatira zabwino pakusinthika kwamitundu yosiyanasiyana yama cell a PRP.Pakalipano, chithandizo cha PRP ndi njira yoyenera yochizira yomwe ili ndi phindu lachipatala, ndipo zotsatira za odwala zomwe zanenedwa zimakhala zolimbikitsa.Komabe, kusagwirizana kwa zotsatira za odwala ndi kuzindikira kwatsopano kwabweretsa zovuta kuti zisagwiritsidwe ntchito pachipatala cha PRP.Chimodzi mwazifukwa chikhoza kukhala chiwerengero ndi kusiyana kwa machitidwe a PRP ndi PRP pamsika.Zidazi ndizosiyana malinga ndi kuchuluka kwa zosonkhanitsira za PRP ndi chiwembu chokonzekera, zomwe zimapangitsa kuti pakhale mawonekedwe apadera a PRP ndi othandizira azachilengedwe.Kuonjezera apo, kusowa kwa mgwirizano pa kukhazikitsidwa kwa dongosolo la kukonzekera kwa PRP ndi lipoti lonse la tizilombo toyambitsa matenda mu ntchito yachipatala zinayambitsa zotsatira zosagwirizana ndi malipoti.Zoyesera zambiri zapangidwa kuti ziwonetsere ndikuyika PRP kapena zinthu zochokera m'magazi muzogwiritsira ntchito mankhwala obwezeretsa.Kuphatikiza apo, zotuluka m'mapulateleti, monga ma lysates a m'magazi a anthu, apangidwa kuti azifufuza za mafupa ndi in vitro stem cell.

 

Chimodzi mwa ndemanga zoyamba za PRP chinasindikizidwa mu 2006. Cholinga chachikulu cha ndemangayi ndi ntchito ndi machitidwe a mapulateleti, zotsatira za PRP pa gawo lililonse la machiritso a machiritso, ndi gawo lalikulu la kukula kwa platelet-derived growth factor. mu zizindikiro zosiyanasiyana za PRP.Kumayambiriro kwa kafukufuku wa PRP, chidwi chachikulu cha PRP kapena PRP-gel chinali kukhalapo ndi ntchito zenizeni za zinthu zingapo za kukula kwa mapulateleti (PGF).

 

Mu pepalali, tikambirana zambiri zakukula kwaposachedwa kwamitundu yosiyanasiyana ya PRP ndi ma cell cell membrane receptors ndi zotsatira zake pakuwongolera chitetezo chamthupi komanso chosinthika.Kuonjezera apo, ntchito ya maselo omwe angakhalepo mu vial ya mankhwala a PRP ndi mphamvu zawo pa njira yokonzanso minofu idzakambidwa mwatsatanetsatane.Kuonjezera apo, kupita patsogolo kwaposachedwa pakumvetsetsa PRP biological agents, mlingo wa platelet, zotsatira zenizeni za maselo oyera a magazi, ndi zotsatira za PGF ndende ndi ma cytokines pa zotsatira za zakudya za mesenchymal stem cell (MSCs) zidzafotokozedwa, kuphatikizapo PRP ikuyang'ana zosiyana. ma cell ndi minofu pambuyo potengera ma cell ndi zotsatira za paracrine.Mofananamo, tidzakambirana njira ya PRP yokhudzana ndi kutupa ndi angiogenesis panthawi yokonza minofu ndi kusinthika.Potsirizira pake, tidzawonanso zotsatira za analgesic za PRP, zotsatira za mankhwala ena pa ntchito ya PRP, ndi kuphatikiza kwa PRP ndi mapulogalamu okonzanso.

 

Mfundo zoyambira zamatenda a plasma okhala ndi mapulateleti

Kukonzekera kwa PRP kukuchulukirachulukira ndipo kumagwiritsidwa ntchito kwambiri m'magawo osiyanasiyana azachipatala.Mfundo yaikulu ya sayansi ya chithandizo cha PRP ndi yakuti jekeseni wa mapulateleti okhazikika pa malo ovulala akhoza kuyambitsa kukonzanso kwa minofu, kaphatikizidwe ka minofu yatsopano yolumikizana ndi kukonzanso kwa magazi mwa kutulutsa zinthu zambiri zomwe zimagwira ntchito pa biologically (zinthu za kukula, cytokines, lysosomes) ndi mapuloteni omatira omwe amachititsa kuti pakhale hemostatic cascade reaction.Kuphatikiza apo, mapuloteni a plasma (mwachitsanzo, fibrinogen, prothrombin, ndi fibronectin) amapezeka m'zigawo za plasma (PPPs).Kukhazikika kwa PRP kungapangitse kumasulidwa kwa hyperphysiological kwa kukula kwa zinthu kuti ayambe kuchiritsa kwa kuvulala kosatha ndikufulumizitsa kukonzanso kwa kuvulala koopsa.Pazigawo zonse za kukonzanso minofu, mitundu yosiyanasiyana ya kukula, ma cytokines ndi owongolera zochita zakomweko amalimbikitsa magwiridwe antchito a cell kudzera mu endocrine, paracrine, autocrine ndi endocrine.Ubwino waukulu wa PRP umaphatikizapo chitetezo chake ndi luso lokonzekera mwanzeru zipangizo zamakono zamalonda, zomwe zingagwiritsidwe ntchito pokonzekera tizilombo toyambitsa matenda zomwe zingagwiritsidwe ntchito kwambiri.Chofunika kwambiri, poyerekeza ndi corticosteroids wamba, PRP ndi chinthu chodziwikiratu popanda zotsatira zake zodziwika.Komabe, palibe malamulo omveka bwino pa ndondomeko ndi mapangidwe a jekeseni wa PRP, ndipo mapangidwe a PRP ali ndi kusintha kwakukulu kwa mapulateleti, maselo oyera a magazi (WBC), kuwonongeka kwa maselo ofiira a magazi (RBC), ndi PGF.

 

PRP terminology ndi classification

Kwa zaka zambiri, kupanga zinthu za PRP zomwe zimagwiritsidwa ntchito polimbikitsa kukonzanso minofu ndi kusinthika kwakhala gawo lofunikira lofufuzira la biomaterials ndi sayansi ya mankhwala.Kuchiritsa kwa minofu kumaphatikizapo otenga nawo mbali ambiri, kuphatikiza mapulateleti ndi zinthu zomwe amakula ndi ma cytokine granules, maselo oyera amagazi, matrix a fibrin ndi ma cytokines ena ambiri.Munjira iyi, njira yovuta yolumikizira idzachitika, kuphatikiza kutsegulira kwa mapulateleti ndi kachulukidwe kotsatira ndi α- Kutulutsidwa kwa zomwe zili m'mapulateleti, kuphatikizika kwa fibrinogen (yotulutsidwa ndi mapulateleti kapena yaulere mu plasma) mu network ya fibrin, ndi mapangidwe. matenda a platelet embolism.

 

"Universal" PRP imayerekezera chiyambi cha machiritso

Poyamba, mawu akuti “platelet-rich plasma (PRP)” ankatchedwa kuti platelet concentrate omwe amagwiritsidwa ntchito popereka magazi, ndipo amagwiritsidwanso ntchito masiku ano.Poyambirira, zinthu za PRPzi zinkangogwiritsidwa ntchito ngati zomatira minofu ya fibrin, pamene mapulateleti ankangogwiritsidwa ntchito kuthandizira polymerization yamphamvu ya fibrin kuti apititse patsogolo kusindikiza kwa minofu, m'malo molimbikitsa machiritso.Pambuyo pake, teknoloji ya PRP idapangidwa kuti iwonetsere kuyambika kwa machiritso.Pambuyo pake, ukadaulo wa PRP udafotokozedwa mwachidule kudzera mu kuthekera kwake koyambitsa ndi kumasula zinthu zakukulira m'malo ocheperako.Chisangalalo chotere cha PGF chopereka nthawi zambiri chimabisala mbali yofunika ya zigawo zina muzotuluka m'magazi.Chidwichi chikukulirakulira chifukwa cha kusowa kwa chidziwitso cha sayansi, zikhulupiriro zachinsinsi, zokonda zamalonda komanso kusowa kokhazikika komanso kusanja.

Biology ya PRP concentrate ndi yovuta ngati magazi okha, ndipo ikhoza kukhala yovuta kuposa mankhwala achikhalidwe.Zogulitsa za PRP ndi biomatadium.Zotsatira za ntchito yachipatala ya PRP zimadalira zizindikiro zamkati, zapadziko lonse komanso zosinthika za magazi a wodwalayo, kuphatikizapo zigawo zina zamagulu zomwe zingakhalepo mu chitsanzo cha PRP ndi microenvironment ya m'deralo ya receptor, yomwe ingakhale yovuta kapena yovuta.

 

Chidule cha kusokoneza terminology ya PRP ndi kachitidwe kagawo kagawo

Kwa zaka zambiri, akatswiri, asayansi ndi makampani akhala akuvutika ndi kusamvetsetsana koyamba ndi zolakwika za mankhwala a PRP ndi mawu awo osiyanasiyana.Olemba ena amatanthauzira PRP ngati mapulateleti okha, pamene ena adanena kuti PRP imakhalanso ndi maselo ofiira a magazi, maselo oyera a magazi, fibrin ndi mapuloteni a bioactive omwe ali ndi chiwerengero chowonjezeka.Chifukwa chake, othandizira ambiri a PRP azachilengedwe adayambitsidwa muzochita zamankhwala.Ndizokhumudwitsa kuti mabuku nthawi zambiri alibe kufotokoza mwatsatanetsatane za tizilombo toyambitsa matenda.Kulephera kwa kukhazikitsidwa kwa kukonzekera kwa mankhwala ndi chitukuko chotsatira chamagulu chinayambitsa kugwiritsa ntchito zinthu zambiri za PRP zomwe zimafotokozedwa ndi mawu ndi zidule zosiyanasiyana.N'zosadabwitsa kuti kusintha kwa kukonzekera kwa PRP kumabweretsa zotsatira zosagwirizana ndi odwala.

 

Kingsley anayamba kugwiritsa ntchito mawu akuti "plasma-rich plasma" mu 1954. Zaka zambiri pambuyo pake, Ehrenfest et al.Dongosolo loyamba lamagulu ozikidwa pamitundu itatu yayikulu (mapulateleti, leukocyte ndi fibrin zili) adafunsidwa, ndipo zinthu zambiri za PRP zidagawidwa m'magulu anayi: P-PRP, LR-PRP, fibrin yolemera kwambiri ya platelet (P-PRF) ndi leukocyte. wolemera PRF (L-PRF).Zogulitsazi zimakonzedwa ndi makina otsekedwa okha kapena ma protocol amanja.Pakadali pano, Everts et al.Kufunika kotchula maselo oyera a magazi mu kukonzekera kwa PRP kunagogomezedwa.Amalimbikitsanso kugwiritsa ntchito mawu oyenerera kuti awonetse kusinthika kapena kusinthidwa kwa kukonzekera kwa PRP ndi gel osakaniza.

Delong et al.anakonza dongosolo la PRP lotchedwa platelets, activated white blood cells (PAW) kutengera chiwerengero chonse cha mapulateleti, kuphatikizapo magawo anayi a mapulateleti.Zigawo zina ndi monga kugwiritsa ntchito zoyambitsa mapulateleti ndi kukhalapo kapena kusapezeka kwa maselo oyera a magazi (ie neutrophils).Mishra et al.Dongosolo lofananira lamagulu likuperekedwa.Zaka zingapo pambuyo pake, Mautner ndi anzake adalongosola ndondomeko yowonjezereka komanso yowonjezera (PLRA).Wolembayo adatsimikizira kuti ndikofunikira kufotokozera kuchuluka kwa mapulateleti, kuchuluka kwa maselo oyera amagazi (zabwino kapena zoyipa), kuchuluka kwa neutrophil, RBC (zabwino kapena zoyipa) komanso ngati kuyambitsa kwakunja kumagwiritsidwa ntchito.Mu 2016, Magalon et al.Gulu la DEPA lotengera mlingo wa jakisoni wa mapulateleti, kupanga bwino, chiyero cha PRP chopezedwa ndi njira yoyambitsa zidasindikizidwa.Pambuyo pake, Lana ndi anzake adayambitsa dongosolo la MARSPILL, lomwe limayang'ana kwambiri ma cell amagazi amtundu wa mononuclear.Posachedwa, Scientific Standardization Committee idalimbikitsa kugwiritsidwa ntchito kwa gulu la International Society for Thrombosis and Hemostasis, lomwe latengera malingaliro angapo ogwirizana kuti akhazikitse kugwiritsidwa ntchito kwa mapulateleti pakugwiritsa ntchito mankhwala obwezeretsanso, kuphatikiza mankhwala oundana komanso osungunuka.

Malingana ndi dongosolo la PRP lopangidwa ndi akatswiri osiyanasiyana ndi ochita kafukufuku, zoyesayesa zambiri zosagwira ntchito zoyesa kupanga, kutanthauzira ndi ndondomeko ya PRP kuti igwiritsidwe ntchito ndi madokotala akhoza kupeza mfundo yoyenera, zomwe sizingachitike m'zaka zingapo zikubwerazi Kuwonjezera pamenepo. , teknoloji ya mankhwala a PRP yachipatala ikupitirizabe kukula, ndipo deta ya sayansi imasonyeza kuti kukonzekera kosiyana kwa PRP kumafunika kuchiza matenda osiyanasiyana pazikhalidwe zinazake.Choncho, tikuyembekeza kuti magawo ndi zosiyana za kupanga PRP zabwino zidzapitirira kukula m'tsogolomu.

 

Njira yokonzekera PRP ikuchitika

Malinga ndi mawu a PRP ndi kufotokozera kwazinthu, machitidwe angapo amagawidwe amamasulidwa pamapangidwe osiyanasiyana a PRP.Tsoka ilo, palibe mgwirizano pa dongosolo lonse la magawo a PRP kapena magazi ena aliwonse a autologous ndi mankhwala a magazi.Momwemo, dongosolo lamagulu liyenera kumvetsera makhalidwe osiyanasiyana a PRP, matanthauzo ndi mayina oyenerera okhudzana ndi zisankho zachipatala za odwala omwe ali ndi matenda enieni.Pakalipano, ntchito za mafupa zimagawa PRP m'magulu atatu: pure platelet-rich fibrin (P-PRF), leucocyte-rich PRP (LR-PRP) ndi leukocyte-deficient PRP (LP-PRP).Ngakhale ndizodziwika bwino kwambiri kuposa tanthauzo lazinthu zonse za PRP, magulu a LR-PRP ndi LP-PRP mwachiwonekere alibe chilichonse chokhudza maselo oyera amwazi.Chifukwa cha chitetezo cha mthupi komanso chitetezo, maselo oyera amagazi akhudza kwambiri biology ya matenda osachiritsika.Choncho, mankhwala a PRP omwe ali ndi maselo oyera a magazi amatha kulimbikitsa kwambiri chitetezo cha mthupi komanso kukonzanso minofu ndi kusinthika.Makamaka, ma lymphocyte ndi ochuluka mu PRP, amatulutsa insulini yofanana ndi kukula kwa chinthu ndikuthandizira kukonzanso minofu.

Ma monocyte ndi macrophages amagwira ntchito yofunika kwambiri pakuwongolera chitetezo chamthupi komanso njira yokonzanso minofu.Kufunika kwa neutrophils mu PRP sikudziwika bwino.LP-PRP idatsimikiziridwa ngati kukonzekera koyamba kwa PRP mwa kuwunika mwadongosolo kuti tipeze zotsatira zabwino za chithandizo cha OA yolumikizana.Komabe, Lana et al.Kugwiritsiridwa ntchito kwa LP-PRP pochiza mawondo OA kumatsutsidwa, zomwe zimasonyeza kuti maselo oyera a magazi enieni amagwira ntchito yofunika kwambiri pazochitika zotupa musanayambe kusinthika kwa minofu, chifukwa amamasula mamolekyu a pro-inflammatory and anti-inflammatory.Iwo adapeza kuti kuphatikiza kwa neutrophils ndi mapulateleti otsegulidwa kunali ndi zotsatira zabwino kuposa zoyipa pakukonza minofu.Iwo adanenanso kuti pulasitiki ya monocytes ndi yofunika kuti ikhale yosapweteka komanso yokonzanso ntchito yokonza minofu.

Lipoti la ndondomeko yokonzekera PRP mu kafukufuku wachipatala ndi losagwirizana kwambiri.Kafukufuku wofalitsidwa kwambiri sanapereke njira yokonzekera PRP yofunikira kuti chiwembucho chibwerezedwe.Palibe mgwirizano womveka bwino pakati pa zizindikiro za chithandizo, choncho n'zovuta kuyerekezera mankhwala a PRP ndi zotsatira zake za mankhwala.Nthawi zambiri, chithandizo chamankhwala apulateleti chimayikidwa pansi pa mawu akuti "PRP", ngakhale pachiwonetsero chomwecho chachipatala.Kwa madera ena azachipatala (monga OA ndi tendinosis), kupita patsogolo kwapangidwa pomvetsetsa kusintha kwa kukonzekera kwa PRP, njira zoperekera, ntchito za platelet ndi zigawo zina za PRP zomwe zimakhudza kukonza minofu ndi kusinthika kwa minofu.Komabe, kafukufuku wowonjezereka akufunika kuti agwirizane ndi mawu a PRP okhudzana ndi PRP biological agents kuti athe kuchiza matenda ndi matenda ena.

 

Mkhalidwe wa PRP classification system

Kugwiritsiridwa ntchito kwa autologous PRP biotherapy kumavutitsidwa ndi kusiyanasiyana kwa kukonzekera kwa PRP, kutchula dzina losagwirizana ndi kusamalidwa bwino kwa malangizo okhudzana ndi umboni (ndiko kuti, pali njira zambiri zokonzekera kuti apange mbale zachipatala).Zitha kunenedweratu kuti mtheradi wa PRP, chiyero ndi makhalidwe achilengedwe a PRP ndi mankhwala okhudzana nawo amasiyana kwambiri, ndipo zimakhudza mphamvu ya zamoyo ndi zotsatira za mayesero achipatala.Kusankhidwa kwa chipangizo chokonzekera PRP kumayambitsa kusintha kofunikira koyamba.M'mankhwala obwezeretsanso azachipatala, akatswiri amatha kugwiritsa ntchito zida ziwiri zokonzekera za PRP ndi njira.Kukonzekera kumagwiritsira ntchito cholekanitsa maselo a magazi, chomwe chimagwira ntchito pamagazi athunthu omwe amasonkhanitsidwa okha.Njirayi imagwiritsa ntchito ng'oma yosalekeza ya centrifuge kapena ukadaulo wolekanitsa litayamba ndi njira zolimba komanso zofewa za centrifuge.Zambiri mwa zidazi zimagwiritsidwa ntchito popanga opaleshoni.Njira ina ndiyo kugwiritsa ntchito ukadaulo wa gravity centrifugal ndi zida.High G-force centrifugation imagwiritsidwa ntchito kulekanitsa gawo lachikasu la ESR kugawo lamagazi lomwe lili ndi mapulateleti ndi maselo oyera amagazi.Zida zochepetsera izi ndi zazing'ono kuposa zolekanitsa maselo a magazi ndipo zitha kugwiritsidwa ntchito pambali pa bedi.Mosiyana ģ - Nthawi ya mphamvu ndi centrifugation imatsogolera ku kusiyana kwakukulu pa zokolola, ndende, chiyero, kuthekera, ndi kutsegulidwa kwa mapulateleti akutali.Mitundu yambiri ya zida zokonzekera za PRP zitha kugwiritsidwa ntchito m'gulu lomaliza, zomwe zimapangitsa kuti pakhale kusintha kwina pazogulitsa.

Kuperewera kwa mgwirizano pa njira yokonzekera ndi kutsimikiziridwa kwa PRP kukupitirizabe kusagwirizana ndi chithandizo cha PRP, ndipo pali kusiyana kwakukulu pakukonzekera PRP, khalidwe lachitsanzo ndi zotsatira zachipatala.Zida zamalonda za PRP zomwe zilipo kale zatsimikiziridwa ndikulembetsedwa molingana ndi ndondomeko ya wopanga eni, zomwe zimathetsa zosiyana siyana pakati pa zipangizo za PRP zomwe zilipo panopa.

 

Kumvetsetsa mlingo wa platelet mu vitro ndi mu vivo

Mphamvu yochiritsira ya PRP ndi mapulateleti ena amayang'ana kwambiri amachokera ku kutulutsidwa kwa zinthu zosiyanasiyana zomwe zimakhudzidwa ndi kukonzanso minofu ndi kusinthika.Pambuyo poyambitsa mapulateleti, mapulateleti amapanga thrombus yamagazi, yomwe idzakhala ngati matrix kwakanthawi kochepa kuti ilimbikitse kuchulukana kwa maselo ndi kusiyanitsa.Chifukwa chake, ndizabwino kuganiza kuti kuchuluka kwa mapulateleti kumapangitsa kuti pakhale kuchuluka kwa zinthu zam'magazi zamagazi.Komabe, kugwirizana pakati pa mlingo ndi kuchuluka kwa mapulateleti ndi kuchuluka kwa kutulutsidwa kwa platelet bioactive kukula factor ndi mankhwala kungakhale kosalamulirika, chifukwa pali kusiyana kwakukulu mu chiwerengero choyambirira cha platelet pakati pa odwala payekha, ndipo pali kusiyana pakati pa njira zokonzekera PRP.Momwemonso, zinthu zingapo za kukula kwa mapulateleti zomwe zimakhudzidwa ndi njira yokonzanso minofu zilipo mu gawo la plasma la PRP (mwachitsanzo, kukula kwa chiwindi ndi insulin-monga kukula factor 1).Choncho, mlingo wapamwamba wa platelet sudzakhudza kukonzanso kwa zinthu izi za kukula.

Kafukufuku wa in vitro PRP ndiwotchuka kwambiri chifukwa magawo osiyanasiyana mu maphunzirowa amatha kuyendetsedwa molondola ndipo zotsatira zake zitha kupezeka mwachangu.Kafukufuku wambiri wasonyeza kuti maselo amayankha PRP motengera mlingo.Nguyen ndi Pham adawonetsa kuti kuchuluka kwambiri kwa GF sikunali kothandiza pakukondoweza kwa ma cell, komwe kungakhale kopanda phindu.Kafukufuku wina wa in vitro awonetsa kuti kuchuluka kwa PGF kumatha kukhala ndi zotsatira zoyipa.Chifukwa chimodzi chingakhale kuchuluka kwa ma cell membrane receptors.Chifukwa chake, mulingo wa PGF ukakwera kwambiri poyerekeza ndi zolandilira zomwe zilipo, zimakhala ndi zotsatira zoyipa pama cell.

 

Kufunika kwa data ya mapulateleti mu vitro

Ngakhale kafukufuku wa in vitro ali ndi zabwino zambiri, alinso ndi zovuta zina.In vitro, chifukwa cha kuyanjana kosalekeza pakati pa mitundu yosiyanasiyana ya maselo mumtundu uliwonse chifukwa cha mawonekedwe a minofu ndi minofu ya ma cell, zimakhala zovuta kubwereza mu vitro mu chikhalidwe chimodzi chamitundu iwiri.Kuchulukana kwa ma cell komwe kumatha kukhudza njira yama cell nthawi zambiri kumakhala kochepera 1% ya minofu.Minofu yamitundu iwiri yamitundu iwiri imalepheretsa ma cell kuti asawonekere ku extracellular matrix (ECM).Kuphatikiza apo, ukadaulo wachikhalidwe wanthawi zonse umapangitsa kuti pakhale kuchulukirachulukira kwa zinyalala zama cell komanso kugwiritsa ntchito michere mosalekeza.Choncho, chikhalidwe cha in vitro ndi chosiyana ndi chikhalidwe chilichonse chokhazikika, mpweya wa okosijeni wa minofu kapena kusinthana kwadzidzidzi kwa chikhalidwe cha chikhalidwe, ndipo zotsatira zotsutsana zasindikizidwa, poyerekeza zotsatira zachipatala za PRP ndi maphunziro a in vitro a maselo enieni, mitundu ya minofu ndi mapulateleti. zokhazikika.Graziani ndi ena.Zinapezeka kuti mu vitro, zotsatira zazikulu za kufalikira kwa osteoblasts ndi fibroblasts zinapezedwa pa PRP platelet concentration 2.5 times kuposa mtengo woyambira.Mosiyana ndi zimenezi, deta yachipatala yoperekedwa ndi Park ndi anzake inasonyeza kuti pambuyo pa kusakanikirana kwa msana, mlingo wa platelet wa PRP uyenera kuwonjezeka ndi nthawi zoposa 5 kuposa zoyambira kuti apange zotsatira zabwino.Zotsatira zotsutsana zofananira zidanenedwanso pakati pa kuchuluka kwa tendon mu vitro ndi zotsatira zachipatala.

 

 

 

(Zomwe zili m'nkhaniyi zidasindikizidwanso, ndipo sitikupereka chitsimikizo chotsimikizika kapena chotsimikizika pakulondola, kudalirika kapena kukwanira kwa zomwe zili m'nkhaniyi, ndipo sitili ndi udindo pamalingaliro ankhaniyi, chonde mvetsetsani.)


Nthawi yotumiza: Mar-01-2023